Search results for "prenatal diazepam"

showing 4 items of 4 documents

Long-lasting handling affects behavioural reactivity in adult rats of both sexes prenatally exposed to diazepam

2001

Environmental stressors can substantially affect the adaptive response of rats to novelty in a sexually dimorphic manner. Gender-related differences are also observed in neurochemical and behavioural patterns of adult rats following prenatal exposure to diazepam (DZ). In the present study the behavioural reactivity to novelty is investigated in open field (OF) and in acoustic startle reflex (ASR) tests, in non handled (NH), short-lasting handled (SLH) and long-lasting handled (LLH) adult male and female rats prenatally exposed to DZ. A single daily s.c. injection of DZ (1.5 mg/kg) over gestation days 14-20 decreases GABA/BDZ receptor function in both sexes, as shown by the decreased electro…

MaleReflex Startlemedicine.medical_specialtySettore BIO/14 - FARMACOLOGIAHippocampal formationHandling PsychologicalOpen fieldchemistry.chemical_compoundNeurochemicalPregnancyInternal medicinegendermedicineAnimalsprenatal diazepamRats Wistarprenatal diazepam; handling; gender; behavioral reactivitybehavioral reactivityMolecular BiologySex CharacteristicsDiazepamHandlingGeneral NeuroscienceRatsSexual dimorphismEndocrinologyAnti-Anxiety AgentschemistryPrenatal Exposure Delayed EffectsAcoustic Startle ReflexExploratory BehaviorRatGestationFemaleNeurology (clinical)PsychologyDiazepamDevelopmental Biologymedicine.drugPicrotoxinBrain Research
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Effects of 8-OH-DPAT on open field performance of young and aged rats prenatally exposed to diazepam: a tool to rveal 5-HT1a receptor function

2003

Central GABAergic and serotoninergic systems interact with one another and are implicated in controlling different behaviours. A gentle early long-lasting handling can prevent the deficits in locomotion and exploration in open field (O.F.) in 3-month-old male rats prenatally exposed to diazepam (DZ). Purpose of this study was to extend the research to older handled rats prenatally exposed to DZ and to assess the activity of 5-HT1A receptors (Rs), evaluating the performance in O.F. at 3 and 18 months of age following 8-OH-DPAT administration. A single daily s.c. injection of DZ (1.5 mg/kg) from gestation day 14 to gestation day 20 induced in aged, but not in young rats, a decrease in total d…

Open field testAging8-OH-DPATLong-lasting handlingSettore BIO/14 - FarmacologiaRatPrenatal diazepam
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Reversal of prenatal diazepam-induced deficit in a spatial-object learning task by brief, periodic maternal separation in adult rats.

2005

In the rat, prenatal exposure to diazepam (DZ) induces a permanent reduction in GABA/BZ receptor (R) function and behavioural abnormalities. Environmental modifications during early stages of life can influence brain development and induce neurobiological and behavioural changes throughout adulthood. Indeed, a subtle, periodic, postnatal manipulation increases GABA/BZ R activity and produces facilitatory effects on neuroendocrine and behavioural responses. We here investigated the impact of prenatal treatment with DZ on learning performance in adult 3- and 8-month-old male rats and the influence of a brief, periodic maternal separation on the effects exerted by prenatal DZ exposure. Learnin…

Malemedicine.medical_specialtyReflex StartleSettore BIO/14 - FARMACOLOGIASpatial BehaviorMotor ActivityOpen fieldDevelopmental psychologyBehavioral NeuroscienceEmotionalityPregnancyInternal medicineNeuroplasticitymedicinedeficit in learningAnimalsratlearning performanceprenatal diazepamRats WistarGABA ModulatorsMaze LearningemotionalityAnalysis of VarianceDiazepamBehavior AnimalLearning DisabilitiesMaternal DeprivationAge FactorsObject learningmaternal separationbehaviourRatsExploratory behaviourPrenatal treatmentEndocrinologyAcoustic StimulationAnimals NewbornAcoustic Startle ReflexPrenatal Exposure Delayed EffectsExploratory BehaviorLinear ModelsFemalePsychologyDiazepammedicine.drugBehavioural brain research
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Effects of 8-OH-DPAT on open field performance of young and aged rats prenatally exposed to diazepam: a tool to reveal 5-HT1A receptor function

2003

Central GABAergic and serotoninergic systems interact with one another and are implicated in controlling different behaviours. A gentle early long-lasting handling can prevent the deficits in locomotion and exploration in open field (O.F.) in 3-month-old male rats prenatally exposed to diazepam (DZ). Purpose of this study was to extend the research to older handled rats prenatally exposed to DZ and to assess the activity of 5-HT1A receptors (Rs), evaluating the performance in O.F. at 3 and 18 months of age following 8-OH-DPAT administration. A single daily s.c. injection of DZ (1.5 mg/kg) from gestation day 14 to gestation day 20 induced in aged, but not in young rats, a decrease in total d…

MaleAgingmedicine.medical_specialtySettore BIO/14 - FARMACOLOGIARats Prenatal diazepam Long-lasting handling Aging 8-OH-DPAT Open field testMotor ActivityHandling PsychologicalSerotonergicOpen fieldchemistry.chemical_compoundPregnancyInternal medicinemedicineAnimalsPharmacology (medical)Rats WistarReceptorgamma-Aminobutyric AcidBiological PsychiatrydiazepamPharmacology8-Hydroxy-2-(di-n-propylamino)tetralinBehavior Animal8-OH-DPATin utero treatmentRatsSerotonin Receptor AgonistsPsychiatry and Mental healthEndocrinologyAnti-Anxiety AgentsNeurologychemistryPrenatal Exposure Delayed EffectsReceptors Serotonin5-HT1a receptorsGABAergicGestation5-HT1A receptorSettore MED/26 - NeurologiaFemaleNeurology (clinical)PsychologyReceptors Serotonin 5-HT1Diazepammedicine.drugEuropean Neuropsychopharmacology
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